利用生物信息学数据库及软件，对绵羊ADRA1B基因进行生物信息学分析，初步了解其结构并进行预测。结果表明，绵羊ADRA1B基因含有1个1548 bp 的开放阅读框，编码515个氨基酸残基。ADRA1B蛋白分子质量为56 385.55 KDa，理论等电点PI为9.53。亚细胞主要定位于质膜，不属于分泌蛋白。不存在信号肽序列。存在七段跨膜结构且有2段低复杂性区域，二级结构以无规卷曲为主，三级结构主要由无规卷曲缠绕折叠形成。参与心肌、血管、肌肉的收缩调节。

The bioinformatics analysis of sheep ADRA1B gene was carried out by using bioinformatics database and software，and its structure was preliminarily understood and predicted. The results showed that sheep ADRA1B gene contained an open reading frame of 1 548 bp， encoding 515 amino acid residues. The molecular mass of ADRA1B protein was 56 385.55 KDa， and the theoretical isoelectric point PI was 9.53. The subcells were mainly located in plasma membrane and did not belong to secretory protein. There are no signal peptide sequences；There are seven segments of transmembrane structure and two segments of low complexity regions. The secondary structure is mainly random crimp， and the tertiary structure is mainly formed by random crimp， winding and folding. Involved in the regulation of contraction of myocardium， blood vessels and muscles.

S826

甘肃农业大学学生科研训练计划项目(201904030)；甘肃农业大学盛彤笙科技创新基金(GSAU-STS-1618)；甘肃省农业生物技术专项(GNSW-2016-10)。